RBM12

Across TCGA patient cohorts, RBM12 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM12-associated genes across cancer lineages are PDCD4, A-Raf_pS299, and ERK2. Each is linked with RBM12 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBM12-to-partner and partner-to-RBM12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by RBM12-low versus RBM12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM12→partner) and Y-score (partner→RBM12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.433	-1.584	.002	.032	3	3
UCEC	A-Raf_pS299 →	-0.079	-2.222	.029	.009	3	2
UCEC	ERK2 →	+0.156	+1.906	.007	.014	3	2
UCEC	JNK_pT183_Y185 →	-0.139	-1.584	.006	.017	3	2
UCEC	Notch1 →	+0.154	+2.013	<.001	.004	3	2
UCEC	p62 Lck ligand →	+0.357	+2.273	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PDCD4 by RBM12 expression — UCEC

Explore this box plot interactively →