RBM12

Across TCGA cell cohorts, RBM12 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible RBM12-associated genes across cancer lineages are PRR23A, OR2A2, and SLC2A7. Each is linked with RBM12 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM12-to-partner and partner-to-RBM12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23A grouped by RBM12-low versus RBM12-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM12→partner) and Y-score (partner→RBM12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PRR23A →	+0.033	+4.643	<.001	.008	3	2
URINARY_TRACT	OR2A2 →	+0.035	+4.087	<.001	.009	3	1
OESOPHAGUS	SLC2A7 →	+0.016	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUSC	RXFP2 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CSN2 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR13C9 →	+0.090	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PRR23A by RBM12 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →