RBL1

Across TCGA patient cohorts, RBL1 mutation is significantly associated with the RNA expression of many other genes, with 3,436 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBL1-associated genes across cancer lineages are MCM6, BNIP1, and ZWINT. Each is linked with RBL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RBL1-to-partner and partner-to-RBL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM6 grouped by RBL1-low versus RBL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBL1→partner) and Y-score (partner→RBL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCM6 →	+0.541	+2.662	<.001	<.001	3	4
UCEC	BNIP1 →	+0.279	+1.954	<.001	<.001	3	3
UCEC	ZWINT →	+0.693	+1.736	<.001	<.001	3	3
UCEC	ALG10 →	+0.317	+1.401	.005	.004	3	3
UCEC	POLA2 →	+0.441	+2.850	<.001	<.001	3	3
UCEC	LEO1 →	+0.384	+1.747	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,436 associations by consensus.

MCM6 by RBL1 expression — UCEC

Explore this box plot interactively →