RBL1

Across TCGA patient cohorts, RBL1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBL1-associated genes across cancer lineages are PDCD4, TIGAR, and FoxM1. Each is linked with RBL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBL1-to-partner and partner-to-RBL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by RBL1-low versus RBL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBL1→partner) and Y-score (partner→RBL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.651	-2.378	<.001	<.001	3	3
UCEC	TIGAR →	+0.165	+1.847	<.001	.007	3	3
UCEC	FoxM1 →	+0.183	+1.523	.026	.008	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.534	-2.045	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.562	+2.189	<.001	.001	3	2
UCEC	ATM →	-0.569	-2.308	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PDCD4 by RBL1 expression — UCEC

Explore this box plot interactively →