RBKS

Across TCGA patient cohorts, RBKS mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBKS-associated genes across cancer lineages are JNK2, eEF2, and Ku80. Each is linked with RBKS in more than 1 cancer types. Because this analysis shows association rather than direction, both RBKS-to-partner and partner-to-RBKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by RBKS-low versus RBKS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBKS→partner) and Y-score (partner→RBKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.498	+2.817	<.001	.036	3	2
UCEC	eEF2 →	+0.595	+3.000	.003	.037	3	1
UCEC	Ku80 →	+0.353	+3.013	.009	.019	3	1
UCEC	Notch1 →	+0.195	+3.000	.016	.037	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.602	-2.986	.020	.037	3	1
UCEC	p62 Lck ligand →	+0.511	+2.817	.006	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

JNK2 by RBKS expression — UCEC

Explore this box plot interactively →