RBIS

Across TCGA pan-cancer cohorts, RBIS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RBIS data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RBIS mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RBIS expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, GBM, and CCRCC are the cancer types where RBIS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.848	0.288	.003	34	view →
GBM	DFS	Median	All	0.210	0.474	.007	6	view →
CCRCC	DFS	Quartile	All	0.488	1.000	.016	5	view →
UCEC	DFS	Median	All	0.936	1.000	.022	4	view →
HNSC	DFS	Median	III,IV	1.000	0.932	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RBIS–LUAD (OS)

Open the LUAD breakdown →