RBFOX3

Across TCGA patient cohorts, RBFOX3 mutation is significantly associated with the RNA expression of many other genes, with 2,672 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBFOX3-associated genes across cancer lineages are YTHDF3-AS1, DCP1A, and ZNHIT3. Each is linked with RBFOX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBFOX3-to-partner and partner-to-RBFOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YTHDF3-AS1 grouped by RBFOX3-low versus RBFOX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBFOX3→partner) and Y-score (partner→RBFOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YTHDF3-AS1 →	+0.644	+2.375	.001	.003	3	1
UCEC	DCP1A →	+0.719	+3.000	<.001	.001	3	1
UCEC	ZNHIT3 →	+0.473	+3.021	.002	<.001	3	1
UCEC	CASTOR2 →	+0.851	+2.354	<.001	.003	3	1
UCEC	MIR7702 →	+0.202	+4.060	<.001	.006	3	1
UCEC	TMEM269 →	+0.255	+2.354	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,672 associations by consensus.

YTHDF3-AS1 by RBFOX3 expression — UCEC

Explore this box plot interactively →