RBFOX3

Across TCGA cell cohorts, RBFOX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,883 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RBFOX3-associated GO terms across cancer lineages are Positive regulation of double-strand break repair via homologous recombination, Regulation of organelle assembly, and Positive regulation of cilium assembly. Each is linked with RBFOX3 in more than 6 cancer types. Because this analysis shows association rather than direction, both RBFOX3-to-partner and partner-to-RBFOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair via homologous recombination grouped by RBFOX3-low versus RBFOX3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RBFOX3→partner) and Y-score (partner→RBFOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of double-strand break repair via homologous recombination →	+0.073	+0.684	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of organelle assembly →	+0.039	+0.215	<.001	.004	3	7
LUNG_NSCLC_LUSC	Positive regulation of cilium assembly →	+0.066	+0.503	.001	.006	3	7
BLOOD_Leukemia	DNA biosynthetic process →	+0.043	+0.238	.003	.005	3	7
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to organelle →	+0.042	+0.205	<.001	.007	3	7
BREAST	Negative regulation of mRNA metabolic process →	+0.082	+0.201	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,883 associations by consensus.

Positive regulation of double-strand break repair via homologous recombination by RBFOX3 expression — SOFT_TISSUE

Explore this box plot interactively →