RBFOX2

Across TCGA patient cohorts, RBFOX2 mutation is significantly associated with the RNA expression of many other genes, with 1,485 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBFOX2-associated genes across cancer lineages are MIR6806, RNA5SP358, and TOMM22P1. Each is linked with RBFOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBFOX2-to-partner and partner-to-RBFOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6806 grouped by RBFOX2-low versus RBFOX2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBFOX2→partner) and Y-score (partner→RBFOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR6806 →	+0.767	+4.409	<.001	.006	3	2
LUAD	RNA5SP358 →	+0.384	+4.984	<.001	.005	3	2
LUAD	TOMM22P1 →	+0.154	+5.912	<.001	.001	3	2
LUAD	RN7SL837P →	+0.130	+4.984	<.001	.005	3	2
SKCM	RPS4Y2 →	+0.779	+3.645	<.001	.003	3	2
UCEC	ARHGEF10 →	+0.446	+2.094	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,485 associations by consensus.

MIR6806 by RBFOX2 expression — CESC

Explore this box plot interactively →