RBFOX2

Across TCGA patient cohorts, RBFOX2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBFOX2-associated genes across cancer lineages are MSH2, 14-3-3_beta, and eIF4E. Each is linked with RBFOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBFOX2-to-partner and partner-to-RBFOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by RBFOX2-low versus RBFOX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBFOX2→partner) and Y-score (partner→RBFOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.309	-3.880	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.089	-1.673	.007	.040	3	1
UCEC	eIF4E →	+0.197	+2.820	.005	.001	3	1
UCEC	ERK2 →	+0.203	+2.502	.001	.001	3	1
UCEC	Heregulin →	-0.096	-1.321	.019	.029	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.364	+1.495	.032	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MSH2 by RBFOX2 expression — UCEC

Explore this box plot interactively →