RBFOX2

Across TCGA cell cohorts, RBFOX2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBFOX2-associated genes across cancer lineages are F9, NKX2-3, and ITGAD. Each is linked with RBFOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBFOX2-to-partner and partner-to-RBFOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F9 grouped by RBFOX2-low versus RBFOX2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBFOX2→partner) and Y-score (partner→RBFOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	F9 →	+0.016	+4.321	.002	.009	3	1
LARGE_INTESTINE	NKX2-3 →	+0.817	+3.392	<.001	.007	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	SHE →	+0.138	+3.643	<.001	<.001	3	1
LARGE_INTESTINE	SIGLECL1 →	+0.015	+3.562	<.001	.002	3	1
LARGE_INTESTINE	C9orf135 →	+0.122	+2.878	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

F9 by RBFOX2 expression — CNS

Explore this box plot interactively →