RBFA

Across TCGA pan-cancer cohorts, RBFA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RBFA data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RBFA mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RBFA expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where RBFA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.261	0.679	.015	13	view →
LUAD	OS	Median	All	0.999	0.925	.032	7	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.758	.030	4	view →
CCRCC	DFS	Quartile	II,III,IV	0.752	0.933	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RBFA–PDAC (OS)

Open the PDAC breakdown →