RBFA

Across TCGA pan-cancer cohorts, RBFA mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RBFA’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RBFA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RBFA is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, PDAC, and HNSC are the cancer types where RBFA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBFA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−0.520	<.001	11	view →
PDAC	Male	All	−0.630	<.001	8	view →
HNSC	Male	III,IV	−0.370	<.001	8	view →
LUAD	All	All	+0.209	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RBFA–CCRCC

Open the CCRCC breakdown →