RBFA

Across TCGA patient cohorts, RBFA mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBFA-associated genes across cancer lineages are PRDX1, EGFR_pY1068, and ACC1. Each is linked with RBFA in more than 1 cancer types. Because this analysis shows association rather than direction, both RBFA-to-partner and partner-to-RBFA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by RBFA-low versus RBFA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBFA→partner) and Y-score (partner→RBFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.196	+2.700	.035	.006	3	2
UCEC	EGFR_pY1068 →	-0.248	-2.700	.028	.006	3	1
UCEC	ACC1 →	+0.345	+2.000	.035	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.220	-3.169	.003	.019	3	1
UCEC	Ku80 →	+0.283	+2.013	.007	.018	3	1
UCEC	MAPK_pT202_Y204 →	-0.476	-2.000	.024	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

PRDX1 by RBFA expression — UCEC

Explore this box plot interactively →