RBFA

Across TCGA cell cohorts, RBFA mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBFA-associated genes across cancer lineages are MS4A4A, MSGN1, and CPLX4. Each is linked with RBFA in more than 1 cancer types. Because this analysis shows association rather than direction, both RBFA-to-partner and partner-to-RBFA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by RBFA-low versus RBFA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBFA→partner) and Y-score (partner→RBFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.106	+3.678	.006	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	CPLX4 →	+0.024	+4.392	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MS4A4A by RBFA expression — LARGE_INTESTINE

Explore this box plot interactively →