RBCK1

Across TCGA pan-cancer cohorts, RBCK1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RBCK1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RBCK1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RBCK1 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

CCRCC, COAD, and PDAC are the cancer types where RBCK1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBCK1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+0.446	<.001	12	view →
COAD	Male	All	−0.271	<.001	9	view →
PDAC	Male	All	+0.523	<.001	7	view →
HNSC	Male	All	+0.096	.010	4	view →
LSCC	Male	All	−0.088	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RBCK1–CCRCC

Open the CCRCC breakdown →