RBBP8NL

Across TCGA pan-cancer cohorts, RBBP8NL RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RBBP8NL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RBBP8NL RNA is repressed in tumor relative to normal tissue. In most cancer types RBBP8NL is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where RBBP8NL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBBP8NL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.178	<.001	12	view →
KIRP	Male	III,IV	−1.450	<.001	11	view →
COAD	Male	III,IV	+2.105	<.001	10	view →
LUAD	Female	III,IV	+1.503	<.001	9	view →
LUSC	Female	All	+1.927	<.001	8	view →
BLCA	All	All	+1.743	.001	8	view →
READ	Female	All	+2.548	<.001	7	view →
THCA	Male	All	−1.248	<.001	7	view →
UCEC	All	All	+2.443	<.001	6	view →
BRCA	All	III,IV	+1.301	<.001	6	view →
HNSC	All	II,III,IV	−0.614	.007	5	view →
CHOL	All	II,III,IV	+3.719	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RBBP8NL–KIRC

Open the KIRC breakdown →