RBBP8

Across TCGA patient cohorts, RBBP8 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBBP8-associated genes across cancer lineages are Caspase-7-cleavedD198, Annexin-1, and C-Raf. Each is linked with RBBP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBBP8-to-partner and partner-to-RBBP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RBBP8-low versus RBBP8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBBP8→partner) and Y-score (partner→RBBP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.669	+1.765	.002	.014	3	3
UCEC	Annexin-1 →	+0.465	+2.341	.018	.019	3	2
UCEC	C-Raf →	+0.161	+2.502	.002	.001	3	2
UCEC	14-3-3_beta →	-0.095	-1.673	.012	.040	3	1
UCEC	JNK_pT183_Y185 →	-0.172	-2.000	.006	.030	3	1
UCEC	Ku80 →	+0.234	+1.778	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-7-cleavedD198 by RBBP8 expression — UCEC

Explore this box plot interactively →