RBBP5

Across TCGA patient cohorts, RBBP5 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBBP5-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and ERK2. Each is linked with RBBP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBBP5-to-partner and partner-to-RBBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RBBP5-low versus RBBP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBBP5→partner) and Y-score (partner→RBBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.191	+3.335	.018	.005	3	1
UCEC	A-Raf_pS299 →	-0.130	-2.584	.004	.010	3	1
UCEC	ERK2 →	+0.184	+1.678	.012	.023	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-2.074	.005	.005	3	1
UCEC	JNK2 →	+0.285	+2.486	<.001	.009	3	1
UCEC	Ku80 →	+0.237	+1.335	.008	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by RBBP5 expression — UCEC

Explore this box plot interactively →