RBAK

Across TCGA pan-cancer cohorts, RBAK mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RBAK’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RBAK mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RBAK is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where RBAK tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBAK mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+1.684	<.001	9	view →
LSCC	Male	All	+1.528	<.001	9	view →
HNSC	All	All	−0.449	.046	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

RBAK–LUAD

Open the LUAD breakdown →