RB1CC1

Across TCGA pan-cancer cohorts, RB1CC1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RB1CC1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where RB1CC1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RB1CC1 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LSCC, PDAC, and CCRCC are the cancer types where RB1CC1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RB1CC1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.190	<.001	6	view →
PDAC	Female	II,III,IV	−0.344	<.001	4	view →
CCRCC	Male	III,IV	+0.104	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

RB1CC1–LSCC

Open the LSCC breakdown →