RB1

Across TCGA pan-cancer cohorts, RB1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RB1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RB1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RB1 is over-expressed in tumor.

COAD, CCRCC, and LSCC are the cancer types where RB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+0.757	<.001	12	view →
CCRCC	Female	II,III,IV	+0.474	<.001	11	view →
LSCC	Female	II,III,IV	+0.714	<.001	9	view →
HNSC	Male	II,III,IV	+0.584	<.001	8	view →
PDAC	All	All	+0.199	.001	6	view →
LUAD	Male	All	+0.116	.010	4	view →
OV	All	All	+0.368	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

RB1–COAD

Open the COAD breakdown →