RAX

Across TCGA patient cohorts, RAX mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAX-associated genes across cancer lineages are MSH2, PCNA, and 4E-BP1_pT37_T46. Each is linked with RAX in more than 1 cancer types. Because this analysis shows association rather than direction, both RAX-to-partner and partner-to-RAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by RAX-low versus RAX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAX→partner) and Y-score (partner→RAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.288	-3.000	.030	.037	2	1
UCEC	PCNA →	+0.275	+3.000	.027	.037	2	1
UCEC	4E-BP1_pT37_T46 →	-0.582	-3.000	.007	.037	2	1
UCEC	Lck →	+0.270	+3.000	.020	.037	1	1
UCEC	p38-MAPK_pT180_Y182 →	-0.726	-2.986	.005	.037	1	1
UCEC	Rab25 →	-0.526	-3.000	.006	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MSH2 by RAX expression — UCEC

Explore this box plot interactively →