RAVER2

Across TCGA cell cohorts, RAVER2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible RAVER2-associated genes across cancer lineages are POTEM, MPC1L, and CDC20B. Each is linked with RAVER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAVER2-to-partner and partner-to-RAVER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POTEM grouped by RAVER2-low versus RAVER2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAVER2→partner) and Y-score (partner→RAVER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	POTEM →	+0.240	+5.087	<.001	.004	3	1
URINARY_TRACT	MPC1L →	+0.083	+5.087	<.001	.004	3	1
LARGE_INTESTINE	CDC20B →	+0.055	+3.584	.008	.003	3	1
LARGE_INTESTINE	KLHL14 →	+0.136	+2.817	.001	.007	3	1
BREAST	ADAM2 →	+0.326	+3.232	<.001	.006	3	1
BREAST	NEUROD6 →	+0.003	+3.781	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

POTEM by RAVER2 expression — URINARY_TRACT

Explore this box plot interactively →