RAVER2

Across TCGA cell cohorts, RAVER2 mutation is significantly associated with the mutation status of many other genes, with 2,430 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAVER2-associated genes across cancer lineages are BCR, NCOA6, and PLEKHA5. Each is linked with RAVER2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RAVER2-to-partner and partner-to-RAVER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCR grouped by RAVER2-low versus RAVER2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAVER2→partner) and Y-score (partner→RAVER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BCR →	+3.558	+3.095	.008	.008	1	4
LUNG_NSCLC_LUAD	NCOA6 →	+4.187	+5.000	.008	.008	1	4
BLOOD_Leukemia	PLEKHA5 →	+4.894	+4.894	.004	.004	1	3
BREAST	DNM2 →	+4.558	+3.442	.003	.003	1	3
BREAST	IGSF9 →	+4.558	+3.442	.003	.003	1	3
BLOOD_Lymphoma	LTBP3 →	+4.014	+4.969	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,430 associations by consensus.

BCR by RAVER2 expression — BREAST

Explore this box plot interactively →