RAVER1

Across TCGA pan-cancer cohorts, RAVER1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RAVER1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RAVER1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RAVER1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where RAVER1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.558	0.848	<.001	110	view →
PDAC	DFS	Tertile	All	0.916	0.681	.002	23	view →
LUAD	DFS	Median	All	0.828	0.662	.020	5	view →
LSCC	DFS	Median	II,III,IV	1.000	0.419	.008	4	view →
UCEC	OS	Median	All	0.842	0.953	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RAVER1–HNSC (OS)

Open the HNSC breakdown →