RAVER1

Across TCGA patient cohorts, RAVER1 mutation is significantly associated with the RNA expression of many other genes, with 1,530 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAVER1-associated genes across cancer lineages are MICE, TRBV12-5, and UHRF1. Each is linked with RAVER1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAVER1-to-partner and partner-to-RAVER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MICE grouped by RAVER1-low versus RAVER1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAVER1→partner) and Y-score (partner→RAVER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MICE →	+0.250	+2.365	.006	<.001	3	2
UCEC	TRBV12-5 →	+0.264	+2.682	.006	<.001	3	2
UCEC	UHRF1 →	+0.752	+1.858	.001	.005	3	2
UCEC	RPS29P32 →	+0.320	+2.097	.001	.005	3	2
COAD	SEMA4B →	+0.719	+3.210	.003	.009	3	2
COAD	GAS2L1 →	+0.767	+3.210	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,530 associations by consensus.

MICE by RAVER1 expression — UCEC

Explore this box plot interactively →