RAVER1

Across TCGA cell cohorts, RAVER1 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAVER1-associated genes across cancer lineages are C1orf158, SALL3, and WNT8A. Each is linked with RAVER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAVER1-to-partner and partner-to-RAVER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf158 grouped by RAVER1-low versus RAVER1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAVER1→partner) and Y-score (partner→RAVER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	2
BLOOD_Leukemia	SALL3 →	+1.325	+2.926	<.001	.009	3	2
SKIN	WNT8A →	+0.013	+3.345	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	CCR5 →	+0.129	+4.736	<.001	.009	3	2
OVARY	TBX5 →	+0.169	+4.095	<.001	.003	3	2
URINARY_TRACT	DTHD1 →	+0.042	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

C1orf158 by RAVER1 expression — BLOOD_Myeloma

Explore this box plot interactively →