RASSF8

Across TCGA pan-cancer cohorts, RASSF8 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RASSF8 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RASSF8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RASSF8 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where RASSF8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.905	1.000	.022	4	view →
LUAD	DFS	Median	All	0.877	0.542	.028	3	view →
HNSC	OS	Quartile	III,IV	0.784	0.505	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RASSF8–LSCC (OS)

Open the LSCC breakdown →