RASSF8

Across TCGA pan-cancer cohorts, RASSF8 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RASSF8’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RASSF8 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RASSF8 is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where RASSF8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASSF8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	II,III,IV	−0.983	<.001	12	view →
LSCC	Male	II,III,IV	−1.078	<.001	9	view →
LUAD	Female	II,III,IV	−1.029	<.001	9	view →
OV	All	All	−1.070	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RASSF8–CCRCC

Open the CCRCC breakdown →