RASSF8

Across TCGA cell cohorts, RASSF8 mutation is significantly associated with the mutation status of many other genes, with 271 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RASSF8-associated genes across cancer lineages are GPR183, OR5F1, and NDC80. Each is linked with RASSF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both RASSF8-to-partner and partner-to-RASSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR183 grouped by RASSF8-low versus RASSF8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASSF8→partner) and Y-score (partner→RASSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR183 →	+5.087	+4.523	.006	.006	1	3
LUNG_SCLC	OR5F1 →	+2.985	+3.562	.008	.008	1	3
LARGE_INTESTINE	NDC80 →	+5.087	+4.523	.006	.006	1	2
SKIN	OR2B6 →	+5.053	+4.239	.007	.007	1	2
SKIN	VGF →	+5.053	+4.239	.007	.007	1	2
SKIN	FTO →	+5.053	+4.239	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 271 associations by consensus.

GPR183 by RASSF8 expression — LARGE_INTESTINE

Explore this box plot interactively →