RASSF6

Across TCGA patient cohorts, RASSF6 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASSF6-associated genes across cancer lineages are ER-alpha, ERK2, and ACC_pS79. Each is linked with RASSF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASSF6-to-partner and partner-to-RASSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by RASSF6-low versus RASSF6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASSF6→partner) and Y-score (partner→RASSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ER-alpha →	-0.181	-2.987	.035	.035	3	1
SKCM	ERK2 →	+0.211	+3.017	.030	.017	3	1
SKCM	ACC_pS79 →	+0.294	+2.584	.028	.011	3	1
SKCM	HER3_pY1289 →	-0.117	-3.288	.007	.009	3	1
SKCM	PARP_cleaved →	-0.284	-3.321	<.001	.009	3	1
SKCM	Smac →	+0.263	+3.012	.035	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ER-alpha by RASSF6 expression — SKCM

Explore this box plot interactively →