RASSF6

Across TCGA cell cohorts, RASSF6 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RASSF6-associated genes across cancer lineages are MS4A14, ZNF716, and C1orf146. Each is linked with RASSF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASSF6-to-partner and partner-to-RASSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A14 grouped by RASSF6-low versus RASSF6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASSF6→partner) and Y-score (partner→RASSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A14 →	+0.010	+2.791	<.001	.005	3	1
LARGE_INTESTINE	ZNF716 →	+0.290	+3.378	.004	.001	3	1
LARGE_INTESTINE	C1orf146 →	+0.013	+3.240	<.001	.004	3	1
CNS	OR11H6 →	+0.026	+4.321	<.001	.009	3	1
CNS	OR2V2 →	+0.029	+4.754	<.001	.005	3	1
CNS	CYP4A11 →	+0.149	+4.832	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MS4A14 by RASSF6 expression — LARGE_INTESTINE

Explore this box plot interactively →