RASSF5

Across TCGA pan-cancer cohorts, RASSF5 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RASSF5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RASSF5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RASSF5 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where RASSF5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASSF5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.821	<.001	12	view →
HNSC	All	All	−0.550	<.001	9	view →
LUAD	Male	II,III,IV	−0.996	<.001	8	view →
COAD	Female	All	−0.668	<.001	8	view →
LUSC	Male	II,III,IV	−0.942	<.001	7	view →
THCA	All	III,IV	+0.696	<.001	7	view →
UCEC	All	All	−1.434	<.001	6	view →
KICH	All	II,III,IV	−0.828	.003	4	view →
PRAD	All	All	−0.876	<.001	2	view →
KIRP	All	All	+0.616	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RASSF5–KIRC

Open the KIRC breakdown →