RASSF3

Across TCGA pan-cancer cohorts, RASSF3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RASSF3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RASSF3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RASSF3 is over-expressed in tumor, although a few such as LUSC and BLCA show the opposite, repressed pattern.

KIRC, LUSC, and BLCA are the cancer types where RASSF3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASSF3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.011	<.001	11	view →
LUSC	Female	II,III,IV	−1.898	<.001	8	view →
BLCA	All	All	−1.431	.002	8	view →
KICH	Female	All	−1.221	<.001	8	view →
HNSC	All	III,IV	+0.613	.002	8	view →
LIHC	Female	II,III,IV	+1.720	<.001	7	view →
LUAD	All	III,IV	−0.790	<.001	7	view →
KIRP	All	All	+0.625	.002	6	view →
CHOL	Male	All	+2.306	<.001	5	view →
COAD	All	All	−0.442	.002	4	view →
BRCA	All	II,III,IV	−0.420	<.001	4	view →
READ	Female	All	−1.267	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RASSF3–KIRC

Open the KIRC breakdown →