RASSF2

Across TCGA patient cohorts, RASSF2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASSF2-associated genes across cancer lineages are ASNS, PCNA, and PDCD4. Each is linked with RASSF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RASSF2-to-partner and partner-to-RASSF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RASSF2-low versus RASSF2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASSF2→partner) and Y-score (partner→RASSF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.531	+3.000	.018	.035	3	4
UCEC	PCNA →	+0.174	+2.115	.022	.017	3	2
UCEC	PDCD4 →	-0.374	-1.797	.024	.025	3	2
SKCM	p53 →	+0.270	+2.820	.005	.035	3	1
SKCM	Stathmin →	+0.229	+3.321	.013	.010	3	1
SKCM	Bcl-2 →	-0.451	-3.321	.015	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ASNS by RASSF2 expression — SKCM

Explore this box plot interactively →