RASSF1

Across TCGA pan-cancer cohorts, RASSF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RASSF1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RASSF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RASSF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, GBM, and HNSC are the cancer types where RASSF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.566	0.845	.013	7	view →
GBM	DFS	Tertile	All	0.298	0.551	.013	6	view →
HNSC	DFS	Median	IV	1.000	0.920	.042	3	view →
LUAD	OS	Median	III,IV	0.215	0.641	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RASSF1–LSCC (OS)

Open the LSCC breakdown →