RASSF1-AS1

Across TCGA pan-cancer cohorts, RASSF1-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RASSF1-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RASSF1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RASSF1-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

HNSC, KIRP, and UVM are the cancer types where RASSF1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.771	0.544	<.001	147	view →
KIRP	OS	Quartile	All	1.000	0.881	.003	42	view →
UVM	DFS	Median	All	0.760	0.414	<.001	40	view →
READ	OS	Quartile	II,III,IV	0.961	0.335	.005	32	view →
LGG	DFS	Tertile	All	0.657	0.841	<.001	25	view →
KICH	OS	Median	III,IV	0.766	1.000	.006	24	view →
DLBC	DFS	Median	II,III,IV	0.953	0.674	.017	23	view →
KIRC	DFS	Tertile	II,III,IV	0.423	0.660	.008	22	view →
LUSC	OS	Median	III,IV	0.670	0.361	.001	22	view →
STAD	OS	Median	II,III,IV	0.490	0.341	.003	14	view →
MESO	DFS	Median	IV	0.201	0.482	.018	9	view →
THYM	OS	Median	All	0.956	0.593	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RASSF1-AS1–HNSC (DFS)

Open the HNSC breakdown →