RASL12

Across TCGA patient cohorts, RASL12 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASL12-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and MEK1_p_S217_S221. Each is linked with RASL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASL12-to-partner and partner-to-RASL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RASL12-low versus RASL12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASL12→partner) and Y-score (partner→RASL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.047	+2.341	<.001	.019	3	2
UCEC	eEF2 →	+0.416	+2.999	.012	.035	3	1
UCEC	MEK1_p_S217_S221 →	-0.262	-2.321	.040	.034	3	1
UCEC	MEK1 →	+0.578	+3.459	<.001	.005	3	1
UCEC	mTOR_pS2448 →	-0.185	-3.302	.007	.010	3	1
UCEC	Notch1 →	+0.231	+3.335	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by RASL12 expression — UCEC

Explore this box plot interactively →