RASL10A

Across TCGA pan-cancer cohorts, RASL10A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RASL10A data layer compared with 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher RASL10A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RASL10A expression acts as an unfavorable survival marker, although some lineages such as PAAD and LGG show a favorable association.

MESO, ACC, and PAAD are the cancer types where RASL10A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.411	0.739	<.001	66	view →
ACC	OS	Median	All	0.734	0.985	<.001	62	view →
PAAD	DFS	Quartile	All	0.588	0.338	<.001	62	view →
OV	OS	Median	All	0.634	0.744	.001	58	view →
UVM	DFS	Median	III,IV	0.322	0.757	<.001	57	view →
LGG	OS	Median	All	0.921	0.703	<.001	54	view →
KIRC	DFS	Median	II,III,IV	0.414	0.614	.001	40	view →
BLCA	DFS	Tertile	All	0.372	0.275	.008	21	view →
PRAD	DFS	Median	All	0.690	0.879	<.001	18	view →
CESC	OS	Tertile	All	0.776	0.472	.003	14	view →
HNSC	DFS	Median	III,IV	0.737	0.621	.011	13	view →
LUAD	DFS	Median	IV	0.326	0.766	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RASL10A–MESO (OS)

Open the MESO breakdown →