RASIP1

Across TCGA cell cohorts, RASIP1 mutation is significantly associated with the RNA expression of many other genes, with 558 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RASIP1-associated genes across cancer lineages are OCM2, PRAMEF11, and GRK3. Each is linked with RASIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASIP1-to-partner and partner-to-RASIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OCM2 grouped by RASIP1-low versus RASIP1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASIP1→partner) and Y-score (partner→RASIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OCM2 →	+0.051	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF11 →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	GRK3 →	+0.901	+3.321	<.001	.003	3	1
LARGE_INTESTINE	GCAT →	+1.220	+3.502	.001	.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.430	+2.451	.009	.009	3	1
LARGE_INTESTINE	TNRC6B →	+0.643	+3.502	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 558 associations by consensus.

OCM2 by RASIP1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →