RASGRP3

Across TCGA cell cohorts, RASGRP3 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RASGRP3-associated genes across cancer lineages are OR6M1, ZNRF4, and TAAR5. Each is linked with RASGRP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGRP3-to-partner and partner-to-RASGRP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6M1 grouped by RASGRP3-low versus RASGRP3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRP3→partner) and Y-score (partner→RASGRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR6M1 →	+0.066	+5.285	<.001	.003	3	2
LARGE_INTESTINE	ZNRF4 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TAAR5 →	+0.010	+3.700	<.001	.009	3	1
LARGE_INTESTINE	SCN2A →	+0.487	+3.658	<.001	.003	3	1
LARGE_INTESTINE	GFRA1 →	+0.092	+3.333	.004	.009	3	1
LARGE_INTESTINE	FAM71A →	+0.066	+3.716	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

OR6M1 by RASGRP3 expression — STOMACH

Explore this box plot interactively →