RASGRP1

Across TCGA pan-cancer cohorts, RASGRP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RASGRP1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher RASGRP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RASGRP1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, CCRCC, and LUAD are the cancer types where RASGRP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.866	0.744	.010	6	view →
CCRCC	OS	Tertile	All	0.626	1.000	.049	2	view →
LUAD	OS	Median	II,III,IV	0.841	0.422	.037	2	view →
LSCC	OS	Quartile	All	0.961	0.726	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RASGRP1–GBM (OS)

Open the GBM breakdown →