RASGRP1

Across TCGA patient cohorts, RASGRP1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,232 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RASGRP1-associated genes across cancer lineages are C1QB, C1QA, and PDIA5. Each is linked with RASGRP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RASGRP1-to-partner and partner-to-RASGRP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RASGRP1 versus C1QB in BRCA, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRP1→partner) and Y-score (partner→RASGRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C1QB →	+1.256	+0.443	.003	.008	3	3
BRCA	C1QA →	+0.970	+0.445	.001	<.001	3	3
UCEC	PDIA5 →	-1.186	-0.296	.004	.002	3	3
LSCC	CD4 →	+0.659	+0.549	.002	.002	3	3
LSCC	PNO1 →	-0.656	-0.480	<.001	<.001	3	3
LSCC	HMGA1 →	-0.752	-0.640	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,232 associations by consensus.

RASGRP1 vs C1QB — BRCA

Explore this scatter interactively →