RASGRP1

Across TCGA patient cohorts, RASGRP1 mutation is significantly associated with the RNA expression of many other genes, with 3,801 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASGRP1-associated genes across cancer lineages are MIR5007, RN7SL551P, and SPINT3. Each is linked with RASGRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGRP1-to-partner and partner-to-RASGRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5007 grouped by RASGRP1-low versus RASGRP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRP1→partner) and Y-score (partner→RASGRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR5007 →	+0.217	+2.660	<.001	.002	3	2
READ	RN7SL551P →	+0.150	+4.341	<.001	.007	3	2
CESC	SPINT3 →	+0.085	+4.539	<.001	.008	3	2
CESC	RNA5SP204 →	+0.301	+5.569	<.001	.002	3	2
UCEC	MIR6870 →	+0.270	+1.866	<.001	.004	3	2
SKCM	RRBP1 →	+0.428	+2.925	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,801 associations by consensus.

MIR5007 by RASGRP1 expression — SKCM

Explore this box plot interactively →