RASGRP1

Across TCGA patient cohorts, RASGRP1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASGRP1-associated genes across cancer lineages are ATM, c-Kit, and MSH2. Each is linked with RASGRP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RASGRP1-to-partner and partner-to-RASGRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RASGRP1-low versus RASGRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRP1→partner) and Y-score (partner→RASGRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.562	-2.986	<.001	<.001	3	3
SKCM	c-Kit →	-0.693	-3.321	.041	.010	3	2
UCEC	MSH2 →	-0.277	-1.739	<.001	.012	3	2
UCEC	PDCD4 →	-0.472	-2.700	.002	.005	3	2
UCEC	VHL →	-0.609	-1.415	.006	.043	3	2
UCEC	Caspase-7-cleavedD198 →	+0.642	+1.392	.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by RASGRP1 expression — UCEC

Explore this box plot interactively →