RASGRP1

Across TCGA cell cohorts, RASGRP1 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RASGRP1-associated genes across cancer lineages are MYOD1, TMCO5A, and OR10W1. Each is linked with RASGRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGRP1-to-partner and partner-to-RASGRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by RASGRP1-low versus RASGRP1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRP1→partner) and Y-score (partner→RASGRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MYOD1 →	+0.006	+4.906	<.001	.006	3	2
LARGE_INTESTINE	TMCO5A →	+0.026	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
CNS	ADAMDEC1 →	+0.231	+4.253	<.001	.002	3	1
CNS	OR6K6 →	+0.012	+4.772	<.001	.002	3	1
CNS	OR5T2 →	+0.020	+4.772	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

MYOD1 by RASGRP1 expression — OESOPHAGUS

Explore this box plot interactively →