RASGEF1B

Across TCGA patient cohorts, RASGEF1B protein abundance is significantly associated with the RNA expression of many other genes, with 7,498 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RASGEF1B-associated genes across cancer lineages are BET1, SHC2, and PNPLA8. Each is linked with RASGEF1B in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGEF1B-to-partner and partner-to-RASGEF1B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RASGEF1B versus BET1 in LUAD, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGEF1B→partner) and Y-score (partner→RASGEF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BET1 →	-0.817	-0.703	.008	.005	3	1
LUAD	SHC2 →	+1.666	+0.624	.001	.008	3	1
LUAD	PNPLA8 →	-0.790	-0.745	.009	.002	3	1
LUAD	STX6 →	-0.712	-0.752	.004	.005	3	1
LUAD	COP1 →	-0.724	-0.731	<.001	<.001	3	1
LUAD	SDE2 →	-0.799	-0.639	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,498 associations by consensus.

RASGEF1B vs BET1 — LUAD

Explore this scatter interactively →