RASGEF1B

Across TCGA patient cohorts, RASGEF1B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASGEF1B-associated genes across cancer lineages are PCNA, Shc_pY317, and TFRC. Each is linked with RASGEF1B in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGEF1B-to-partner and partner-to-RASGEF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RASGEF1B-low versus RASGEF1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGEF1B→partner) and Y-score (partner→RASGEF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.279	+2.087	<.001	.005	3	2
UCEC	Shc_pY317 →	-0.160	-2.087	.006	.005	3	2
UCEC	TFRC →	+0.568	+2.459	.005	.018	3	2
UCEC	14-3-3_beta →	-0.095	-1.847	.013	.049	3	1
UCEC	eEF2 →	+0.294	+2.999	.032	.035	3	1
UCEC	A-Raf_pS299 →	-0.150	-2.906	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PCNA by RASGEF1B expression — UCEC

Explore this box plot interactively →