Across TCGA patient cohorts, RASGEF1A mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASGEF1A-associated genes across cancer lineages are PCNA, EGFR_pY1068, and INPP4B. Each is linked with RASGEF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGEF1A-to-partner and partner-to-RASGEF1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGEF1A→partner) and Y-score (partner→RASGEF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.272	+2.321	.002	.006	3	2
UCEC	EGFR_pY1068 →	-0.294	-3.000	.004	.001	3	1
UCEC	INPP4B →	-0.366	-3.584	.006	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.209	-2.986	.002	.001	3	1
UCEC	JNK2 →	+0.225	+1.807	.006	.027	3	1
UCEC	Ku80 →	+0.309	+3.013	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

RASGEF1A survival (RNA) · tumor vs normal (RNA) · all RASGEF1A data types